Articles And Presentations

BASi® scientists regularly participate in conferences and present updates on their research. We frequently receive requests for reprints of these posters from participants at the conference. In the future, we will be directing these requests to this portion of our web site, where copies of the text and data from such presentations will be posted for your convenience. We welcome your feedback and invite you to request more information directly from the listed BASi® scientist.

Pharm Analysis

Method development for equilibrium and kinetic binding in vitro bioequivalence of Colesevelam Hydrochloride in simulated intestinal fluid (SIF)
Adam C. Myers, Ph.D., Josef K. Ludwig, Jennifer L. Sassman, Jonathan W. Henry, Yinyan Zhao, Ph.D.

A Team Approach in CRO for Effective Execution of Analytical Method Development and Validation
Jianming Lei and Maggie McClure Bioanalytical Systems, Inc.

Determination of an Acceptable Preservative for Use in Minocycline Solution Extracts from Antibiotic Impregnated Medical Devices
R. L. Steffen*, A. K. Wilson, D.G. Cuttell, M.S. Medrano, L.R. Brewster, BASi
A. Hoffa, Cook, Inc.

Method Development and Validation of an HPLC Assay for Choline in Carbachol Formulations Using a Post Column Reactor and a Chemically Modified Glassy Carbon Electrode
R.L. Steffen, L. Liu, G. Chong, R. Frank, T. Gibson

Bioanalytical Chemistry

A Single Method for the Quantitiation of Sirolimus (Rapamycin) in Whole Blood and Multiple Tissues
Donald Gray, Tyler DeGraw, Rachel Sun

Automated LC-MS/MS Method to Quantitate Eicosapentaenoic Acid (EPA) in Rat Plasma
Rachel Sun, Jordan Nally, Tim Shoaf

Development of Two High Sensitivity Methods using the AB Sciex QTRAP® 5500 for the Analysis of Low Level Inhalation Compounds
Peter White, Robin Lane, Helen Upton, Julie Chiu, Sue Faulconbridge

Validation of an LC-MS/MS Method for the Determination of Tamiflu„¢ in Human Whole Blood Collected in the DBS Format
Peter White, Robin Lane & Bhavna Mistry

A Pharmacokinetic Evaluation of Acetaminophen in Dog Plasma and Dried Spots Using Automated Blood Collection
V. Cooper, L. Payne , S. Calugaru, L.D. Hopper, P. Downing, A. Hoehn, B. Gien, R. Sun, T. DeGraw

Method Development and Validation of 6-Sulfatoxymelatonin (aMT6s) Quantitation in Human Urine
Rachel Sun, Jordan Nally

Comparison of Dry Blood Spot (DBS) Sampling for Whole Blood with and without Anticoagulant
Hasantha Jayaratna, Rachel Sun, Philip Downing

Evaluation of Chemotherapeutic Agents with Dried Blood Spot Sampling
V. Cooper, Z. DeForrest, K. Fordyce, S. Calugaru, L. Payne, T. Fleischmann
BASi®, McMinnville, OR

Application and Evaluation of a Cross-Validation Exercise of the Dried Blood Spot Technique Between BASi® UK and BASi® US
Neil Doleman (BASi® UK), Robin Lane (BASi® UK) and Rachel Sun (BASi® US)

Validation of an LC-MS/MS Method for the Quantification of Paclitaxel in Porcine Artery, Kidney, Liver, Lung, Muscle, Myocardium, and Spleen Tissues
M. Kiser, S. McConkie, Z. DeForrest
BASi

Method Development and Validation of Cystine in White Blood Cell Lysate Using LC/MS/MS
Rachel Suna, Curtis Smitha, Robert Bethemb, Erica Kraynackc
aBASi®, bIndependent Consultant, cRaptor Therapeutics

Validation of an LC-MS/MS method for the determination of quetiapine, norquetiapine and quetiapine sulphoxide in human whole blood using the Dried Blood Spot technique
Neil Doleman, Robin Lane
BASi®, UK

Development of a Fast, Green LC-MS Method for the Quantification of Oxycodone, Oxymorphone and Noroxycodone Using Innovative HPLC Column Technology
V. Cooper, L. Payne, T. Fleischmann
BASi®, McMinnville, OR

Evaluation of the Dried Blood Spot technique for the quantification of diltiazem in human blood
Neil Doleman, BASi®, UK

Laser Diode Thermal Desorption (LDTD) an Alternative to the LC for High-Throughput Quantitation: Some Early Case Studies
Don Gray, Senior Scientist, BASi

Use Of Noise Parameters to Optimize Data Collection Rates in LC-MS
Michael S. Alexander, Melissa Keiser
BASi® Northwest Laboratory, McMinnville, OR

Quantification of Oxycodone and Its Major Metabolites in Human Plasma by HPLC/MS/MS
Mary E. Leonard, Vance Cooper, Lori Payne
BASi® Northwest Laboratory, McMinnville, OR

Bioanalysis of Ribavirin in Rat Plasma by High Pressure Liquid Chromatography “ Tandem Mass Spectrometry (HPLC-MS/MS)
Lou Anne McKown, Lori Payne
BASi® Northwest Laboratory, McMinnville, OR

Development and Validation of An LC-MS/MS Method for the Quantification of Rapamycin in Porcine Whole Blood and Tissues
Zahuindanda M. DeForrest*, Scott D. McConkie, Peter J. Mann, and Melissa M. Kiser
BASi® Northwest Laboratory, McMinnville, OR

Method Development and Validation of Caffeine and Paraxanthine in Human Plasma
Rachel Sun, Orlando J. Bravo, Brian J. Engel
BASi®, 2701 Kent Avenue, West Lafayette, IN 47906

Validation of Pioglitazone in Human Serum by Two Sample Introduction Methods: LDTD-APCI/MS/MS and LC-ESI/MS/MS
Michael Pugh, Don Gray, Rachel Sun, Brian J. Engel
BASi®, 2701 Kent Avenue, West Lafayette, IN 47906

Mass Spectroscopy in the CRO World
Bernie Monaghan, James Hillis, Mark Wareing
Reprinted with permission from International Labmate

LC/MS/MS Bioanalysis of Acidic and Basic Compounds with Double Liquid-Liquid Extraction by Changing pH in Between (113KB)
Rachel Sun, Gary Overdorf
Bioanalytical Systems, Inc., 2701 Kent Avenue, West Lafayette, IN 47906

Difficulties in Developing a Sensitive Assay for the Quantification of Rifampin in Multiple Biological Matrices by LC-MS/MS (231KB)
Keith D. Zientek, Michael D. Nelson, and Lori Payne
Bioanalytical Systems, Inc. McMinnville, OR

Challenges in Developing a Highly Sensitive LC-MS/MS Method for the Quantification of Rifampin
Lori D. Payne, Keith D. Zientek, and Michael D. Nelson
Bioanalytical Systems, Inc. McMinnville, OR

Analytical Challenges in the Development of an Assay for Capecitabine and Three of its Metabolites
Lori D. Payne* and Ryan Morrison^
*Bioanalytical Systems, Inc., McMinnville, OR
^Pfizer Global Research & Development, Chesterfield, MO

Quantitative Analysis of Benzphetamine in Human Plasma using LC-MS/MS
William G. Sawyers and Paul S. McCafferty
BASi® “ Clinical Research Unit, Baltimore, MD

Quantitative Determination of Delta-9-THC and 11-Hydroxy-Delta-9-THC in Human Plasma Using LC-MS/MS (110KB)
Denise Townsend and William Sawyers
BASi® “ Clinical Research Unit, Baltimore, MD

Quantitative Analysis of Pilocarpine in Human Plasma using LC-MS/MS
Iris Stadelmann and William Sawyers
BASi® “ Clinical Research Unit, Baltimore, MD

Is Your Paclitaxel Method HIV Positive?
Lori D. Payne, Katie J. Amrhein, and Melissa M. Kiser
Bioanalytical Systems, Inc.

Determination of 5-Fluorouracil in Human Plasma Using LC-MS/MS
Lori D. Payne, Michael D. Nelson, Michael S. Alexander, Ryan M. Minikis, and John W. Dolan
Bioanalytical Systems, Inc.

Validation Of An LC/MS/MS Assay For Tenofovir In Human Serum
Sheela Das, Ph.D.

Liquid Chromatography / Tandem Mass Spectrometry for the Determination of Carbamazepine and Its Metabolite in Rat Blood Collected by an Automated Blood Sampling System
Yongxin Zhu, Hwa Jiang, Rita Hilt, Phil Wong, Candice B. Kissinger, and Peter T. Kissinger

Determination of Antioxidants and Phenolic Constituents by Liquid Chromatography with Multi-Channel Electrochemical Detection
Zhu Yongxin, Zhou J, Long H, Tian F, Janle E*, Kissinger P

Increased Sample Throughput For Ketoconazole Analysis By Automated 96-Well Sample Preparation And Multiplexed HPLC
K. Szczap, C. Loop, D. Gray, H. Freiser, R. Shoup, A. Witkowski

Increased Assay Robustness and Throughput Using Automated 96-well Solid Phase Extraction
S. Das, E. Fisher, T. Grever, and B. Burras

Determination of Isoflavones in Natural Sources and Biological Fluids
Feifei Tian, Yongxin Zhu, Hong Long, Fuming Xie, Meloney Cregor, Chester Duda, Elsa Janle and Peter Kissinger

Determination of (-)-Epigallocatechin Gallate in Rat Blood Liquid Chromatography with Multi-Channel Electrochemical Detection and Automated Blood Sampler
Yongxin Zhu, Hong Long, M. Cregor, L. Coury, E. Janle, P.T. Kissinger

Determination of Amprenavir in Human Heparinized Plasma by LC/MS/MS
Ronald E. Shoup, Yingjie Deng, Angela P. Johnson, and David M. Morris

Liquid Chromatography with Multi-Channel Electrochemical Detection for the Determination of (-)-Epigallocatechin Gallate in Rat Blood Utilizing an Automated Blood Sampler

Quantitation of Pamoic Acid in Human, Rat, and Canine Plasma
N. Simmons

Sciex API 3000 Versus Finnigan TSQ 7000: A Head to Head Comparison of Linearity
A. Witkowski, C. Serpe, G. Baker, D. Gray, J. Burrows, K. Watson, J. Chiu

Does Your LC/MS/MS Data Look Better Than it Really Is?
S. Sitaraman, A. Witkowski, J. Plassard, B. Schrader, K. Szczap, and B. Beato

A Novel Approach to Combining Automated Sample Collection, Extraction and Analysis to Obtain PK/PD Information for Preclinical Studies

Automation of Liquid-Liquid Extractions in a 96-Well Format Using the Packard MultiPROBE „¢
S. Sitaraman, T. Grever, and R. Hurd

A Pre-Validation Strategy for Evaluating Bioanalytical Methods
J. Burrows, N. Shearsby, J. Chiu, K. Watson, A. Witkowski

Simultaneous Determination of Caffeine from Blood, Brain and Muscle Using Microdialysis in an Awake Rat and Effect of Caffeine on Rat Activity

Comparison of Conventional Packed Bed, Extraction Disk, and 96-Well Solid Phase Extraction Formats for the Determination of Methotrexate in Plasma
E. C. Hernandez, C. E. Serpe, and A. Witkowski

In Vivo and In Vitro Characterization of a Microdialysis Shunt Probe: Caffeine and Phenolphthalein Glucuronide as Model Compounds

Electrochemical Determination of Lead(II) in Calcium Tablets
Husantha Jayaratna, M.B. Voelz, and C.S. Bruntlett

Automated Sampling from Large Animals

Contact BASi for access to a PDF of any of the following titles:

Pharmacokinetic Evaluation of Diltiazem Comparing Manually-spotted Dried Blood Spots (DBS) with Automated Dried Blood Spots and Plasma Samples, Collected by the BASi Culex ® Automated Sampling System

Comparison of Dried Blood Spot vs. Plasma Sampling Utilizing the BASi Culex L™ Automated Blood Collection System for Canine Pharmacokinetic Studies

Refinement of Blood Collection Techniques to Permit Automated and Low-stress Sampling from Canines

A Pharmacokinetic Evaluation of Acetaminophen in Dog Plasma and Dried Blood Spots Using Automated Blood Collection

ECG and Pharmacokinetic Assessment in the Freely Moving Pig

Measuring Induction of Carbamazepine Metabolism in Pigs Using Automated Blood Sampling

Prototype Device for Computerized Blood Sampling and Data Collection in Freely Moving Swine

Automated Blood Sampling

Contact BASi for access to a PDF of any of the following titles:

A Novel Approach to Automated Glucose Monitoring in Awake and Freely Moving Animals

Automated Blood Sampling and Telemetry Recording in Awake Unrestrained Macaques

The BASi Culex ® Automated In Vivo Sampling System: A Novel Technique for Dried Blood Spot (DBS) Collection in Preclinical Studies

Blood Sampling Method Influences Pharmacokinetics in the Rat

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-b In Vivo.

Synaptic Activity Regulates Interstitial Fluid Amyloid-b Levels In Vivo.

The combination of DSI rat telemetry and the BASi Culex ® Automated Blood Sampler (ABS) for multiparameter safety pharmacology screening.

Force-plate derived quantitative assessment of behavior in the R6/2 mouse model of Huntington™s disease

A New Method for Determining Urine Frequency in Rats

Combinatorial Pharmacology in Mice: Integration of Brain Microdialysis and Automated Blood Collection in a Single Subject

Demonstration of the relationship between in vivo dopamine efflux, behaviour and drug pharmacokinetics

Oral and Intravenous Dosing in Combination with Automated Blood Sampling for a Complete Bioavailability Profile in Mice

Peritoneal Microdialysis with Simultaneous Venous Blood Sampling: Insights into Pharmacokinetics of Free vs. Total Drug in Rodents

Programmed Blood and Bile Collections from Freely-Moving Rats: A Study Tracking Nicotine and its Cotinine Metabolite

Discovery Rat Pharmacokinetic Applications Using the BASi Culex ® Automated Blood Sampler

Use of the BASi Culex ® Bambino to Measure Brain Neurotransmitters, Plasma Corticosterone and Drug Levels with Behaviour in the Same Freely-Moving Rat

Automated Dosing and Sampling System Coupled to LC/MS/MS for the Determination of Endogenous Steroids and DMPK Study

Can Preclinical ADMET-PK Now Be Done More Efficiently and Effectively?

Online Monitoring of Hydrogen Peroxide in Freely-Moving Rodents

Automating Oral Dosing for PK/PD Applications

Continuous Monitoring of Corticosterone in Conscious and Freely-Moving Rats for Anxiolytic Drug Screening

Monitoring Free Drug in Lung Tissue with Concurrent Automated Blood Sampling in the Unrestrained Rat

Use of Behavior as a Pharmacodynamic Parameter During Pharmacokinetics Studies on an Automated Blood Sampler

Evaluation of Post-Surgical Recovery for Rats in an Automated Blood Sampler vs. Rats Returned to a Home Cage

Automated Blood Sampling with Concurrent Electrocardiograms for Laboratory Animals

Influence of Blood Sampling Method on Biometric and Chemical Markers of Stress in the Rat

An Automated Blood Sampler for Pharmacokinetic and Pharmacodynamic Studies

Automated Blood Sampling From Awake Laboratory Animals Coupled to 96-Well Sample Preparation Tools and LC/MSMS Improves Data Quality, Enhances Efficiency and Facilitates Parallel Measurements of Behavior and Physiological Parameters

Monitoring Animal Activity during Automated Blood Sampling: An Early Warning System During First-Pass in Animal Drug Screening

Effects of Blood Sampling Technique on Pharmacokinetics

Experiences with Automated Blood Sampling from Freely Moving Rats for PK/PD Screening

BioTrap Sample Extraction Column: A New Approach for On-Line Sample Presentation in Drug Metabolism Studies

Preclinical

Contact BASi for access to a PDF of any of the following titles:

Demonstration of Simultaneous Automated Blood Sample Collection and Recording of Radiotelemetered Physiologic Measurements in Caged Unrestrained Cynomolgus Macaques

LC/H-ESI MS/MS and Higher Mass Resolution for Quantitative Assay and PK and PD Study Using Automated Blood Sampling Systems

Elimination Of Interanimal Differences By Using A Single Mouse For The Entire PK/PD Study

Continuous Collection of Saliva from an Untethered Human: Implications for Pharmacokinetics and Pharmacodynamics

Absorption Characteristics of an Isolated Segment of Jejunum in a Monkey

Investigation of In Vitro Metabolism of Silibinin in Liver Microsomes and Cytochrome P450 Isozyme Identification

Rapid Quantitative Determination Of Multiple Cytochrome P450 Probe Substrates by Gradient Liquid Chromatography/Electrospray Ionization-Ion Trap Mass Spectrometry

Evaluation of Rats for a New In Vivo Screening Model of Q-T Interval Prolongation by New Chemical Entities

Ultrafiltration Sampling in the Rodent Workstation„¢ to Study the Metabolic Effects of Green Tea on Zucker Diabetic Rats

Effect of Acute Administration of Hypericum Perforatum Extract on Dopamine Release in the Rat Brain

Application of Microdialysis to In Vitro Metabolism Studies

Electrochemistry

Glucose Test Strips and Electroanalytical Chemistry in the Undergraduate Laboratory
Jonathon O. Howell, Bioanalytical Systems Inc., West Lafayette, IN 47906
Peter T. Kissinger, Department of Chemistry, Purdue University, West Lafayette, IN 47907
Arlen D. Kaufman and Hsiang-Jui Yeh, Department of Chemistry, University of Evansville, 1800 Lincoln Avenue, Evansville, IN 47722