Evaluation Of Chemotherapeutic Agents With Dried Blood Spot Sampling

V. Cooper, Z. DeForrest, K. Fordyce, S. Calugaru, L. Payne, T. Fleischmann
BASi®, McMinnville, OR

Background

Utilization of Dried Blood Spots (DBS) as a sample collection technique has received a lot of attention recently due to advantages of collection, storage and transport. However, there are significant challenges to developing bioanalytical DBS assays. The smaller sample volume and resulting decrease in signal requires the extraction recovery and instrument detection to be maximized. Selection of card type is critical to minimize ion suppression and multiple extraction solvents should be investigated as part of a method development program.