ISF Sampling in Dermal and Adipose Tissue - dOFM and aOFM

dOFM – dermal OFM

Linear push-pull type probes that are membrane free wih macroscopic openings
Used for sampling of Peptides, Proteins, Antibodies, Lipophilic Substances, Bound and Unbound Drugs, Transporters, Enzymes, Nanocarriers, Vesicles and Cells
Concentrations and action of dermatological drugs (PK/PD) are measured directly in the dermis.
Transport and effects of drugs are monitored after topical or systemic application (e.g., topical glucocorticoids and systemic antibodies in psoriatic or inflammatory animal models).

aOFM – adipose OFM

Concentrations and action of drugs (PK/PD) are measured directly in adipose tissue.
Independent of the mode of administration (oral, subcutaneous, topical, intravenous or other).
Can be combined with glucose-clamp techniques to investigate e.g. insulin sensitivity as well as insulin concentrations and the effects in subcutaneous tissue.

All a/dOFM supplies are gamma-irradiated (sterile).

Ordering & Specifications
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ISF Sampling in Dermal and Adipose Tissue – dOFM and aOFM

Microperfusion Pump and Accessories

Item Number

Item Description

Specifications

OFM-Pump
(MPP102PC)

Microperfusion Pump Preclinical

2 x 3 channels

Push and pull option integrated in one pump
2 independent controllable pump heads
6 channels (3 per pump head)
Up to 3 push and 3 pull channels
Standard flow rates: 0.1 - 10 µL/min
No flow-rate calibration necessary
Attachable to large animals (dog, pig & primate)
Perfusion buffer delivered in an enclosed, sealed and gamma irradiated bag
Compatible low bind tubing set
Adjustable flow rates: 0.1 - 10μl/min flow rate (with an accuracy of ± 20%)
Resolution:
0.1μl/min at 0.1 – 2.0μl/min flow rate
0.2μl/min at 2.0 – 5.0μl/min flow rate
0.5μl/min at 5.0 – 10.0μl/min flow rate
Typical operating time (with a new battery): up to 48 hours at 1.0μl/min and up to 24 hours at 10μl/min.
Display: LCD with backlight
Dimensions: 130 x 92 x 34.5mm
Total weight: 295g excl. battery and accessories.
Ambient operating temperature: 5 to 40°C

Power Supply with main supply or primary battery
Includes power supply
Battery not included

Microperfusion Pump at a glance

OFM-BAG

Perfusate Bag- 10 ml

(pack of 6)

For use with OFM-Pump
Ready for connection to up to 3 push channels
Can be used with single channel OFM-P-110 or 3 channel OFM-P3-110 push inlet tubings
Bag can be placed into OFM-Pump or externally
Perfusate not included

Standard a/d OFM Probe

Item Number

Item Description

Specifications

a/d OFM-P-15

Linear OFM Probe for Skin and Adipose Tissue

(pack of 6)

Inert & low adsorptive polymer, outer diameter 0.55 mm; inner diameter 0.40 mm, exchange area 15 mm
Shaft length: 200 mm
Includes Mandrel (stainless steel)
Customized diameters available upon request Ask BASi

Standard a/d OFM Tubing Sets

Item Number	Item Description	Specifications
OFM-PH	Single Channel OFM Pump Head Tubing (pack of 6)	Single channel tubing with PEEK port for OFM-Pump Head Used for connecting OFM-LT-1000 tubing (pull side) Must be used with connectors MD-1510 Click here for tubing specs
OFM-P-110	Single Channel Push Tubing (pack of 6)	110 mm length For connection from OFM-BAG to pump head (push side) Luer-Lock pre-mounted for use with OFM-BAG / OFM-Pump Pre-mounted with OFM-PH tubing (push side) Must be used with connectors MD-1510 Click here for tubing specs
OFM-LT-1000	Low Bind Tubing 1000 mm length (pack of 6)	For connection from: OFM-P-110 or OFM-P3-110 (push tubing) to probe inlet, probe outlet to OFM-PH or OFM-PH3 (pull side) to collection vial Can be cut to desired length by the user Must be used with connectors MD-1510 Click here for tubing specs
OFM-PP1-LT-1000	Combined Push Pull Low Bind Tubing (pack of 6)	User for connection to 1 probe Ready to use fully assembled Push-Pull Tubing Can be cut to desired length by the user Click here for tubing specs
OFM-PH3	Three Channel OFM Pump Head Tubing (pack of 6)	3 channel tubing with PEEK-Port for OFM-Pump Head Used for connecting OFM-LT-1000 tubing (pull side) Three channel tubing must be used when all three pump channels are operated at the same time Must be used with connectors MD-1510 Click here for tubing specs
OFM-P3-110	Three Channel Push Tubing (pack of 6)	110 mm length For connection from OFM-BAG to Pump Head (push side) Luer-Lock pre-mounted for use with OFM-BAG / OFM-Pump Pre-mounted with OFM-PH3 tubing (push side) Three channel tubing can be used when all three pump channels are operated at the same time Must be used with connectors MD-1510 Click here for tubing specs
MD-1510	Flanged Tubing Connectors - clear (pack of 20)	Soak connectors in 70% ethanol prior to use. Connectors easily slide on, and then shrink as the alcohol evaporates. (not gamma-irradiated by default, can be gas sterilized upon request when ordering)