ISF Sampling in Dermal and Adipose Tissue - dOFM and aOFM
dOFM – dermal OFM
- Linear Push-pull type probes that are membrane free wih macroscopic openings
- Used for sampling of Peptides, Proteins, Antibodies, Lipophilic Substances, Bound and Unbound Drugs, Transporters, Enzymes, Nanocarriers, Vesicles and Cells
- Concentrations and action of dermatological drugs (PK/PD) are measured directly in the dermis.
- Transport and effects of drugs are monitored after topical or systemic application (e.g., topical glucocorticoids and systemic antibodies in psoriatic or inflammatory animal models).
aOFM – adipose OFM
- Concentrations and action of drugs (PK/PD) are measured directly in adipose tissue.
- Independent of the mode of administration (oral, subcutaneous, topical, intravenous or other).
- Can be combined with glucose-clamp techniques to investigate e.g. insulin sensitivity as well as insulin concentrations and the effects in subcutaneous tissue.
Content coming soon
ISF Sampling in Dermal and Adipose Tissue – dOFM and aOFM
Microperfusion Pump and Accessories
| Item Number | Item Description | Specifications |
| OFM-Pump (MPP102PC) |
Microperfusion Pump Preclinical 2 x 3 channels |
- Power Supply with main supply or primary battery - Includes power supply - Battery not included
|
| OFM-BAG |
Perfusate Bag- 10 ml (pack of 6) |
- For use with OFM-Pump - Ready for connection to up to 3 push channels - Can be used with single channel OFM-P-110 or 3 channel OFM-P3-110 push inlet tubings - Bag can be placed into OFM-Pump or externally - Perfusate not included |
Standard a/d OFM Probe
| Item Number | Item Description | Specifications |
| a/d OFM-P-15 |
Linear OFM Probe for Skin and Adipose Tissue (pack of 6) |
- Inert & low adsorptive polymer, outer diameter 0.55 mm; inner diameter 0.40 mm, exchange area 15 mm - Shaft length: 200 mm - Includes Mandrel (stainless steel) - Customized diameters available upon request Ask BASi |
Standard a/d OFM Tubing Sets
| Item Number | Item Description | Specifications |
| OFM-PH |
Single Channel OFM Pump Head Tubing |
- Single channel tubing with PEEK port for OFM-Pump Head
|
| OFM-P-110 |
Single Channel Push Tubing |
-110 mm length - For connection from OFM-BAG to pump head (push side) - Luer-Lock pre-mounted for use with OFM-BAG / OFM-Pump - Pre-mounted with OFM-PH tubing (push side) - Must be used with connectors MD-1510  Click here for tubing specs |
| OFM-LT-1000 |
Low Bind Tubing |
For connection from: |
| OFM-PP1-LT-1000 |
Combined Push Pull Low Bind Tubing |
- User for connection to 1 probe - Ready to use fully assembled Push-Pull Tubing - Can be cut to desired length by the user  Click here for tubing specs |
| OFM-PH3 |
Three Channel OFM Pump Head Tubing |
- 3 channel tubing with PEEK-Port for OFM-Pump Head |
| OFM-P3-110 |
Three Channel Push Tubing |
- 110 mm length |
| MD-1510 |
Flanged Tubing Connectors - clear |
- Soak connectors in 70% ethanol prior to use. Connectors easily slide on, and then shrink as the alcohol evaporates. |
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Raturn and Caging Options
| MD-1404 | Raturn Microdialysis Stand-Alone System - rat |
| MD-1409 | Raturn Microdialysis Stand-Alone System - mouse |
| AMD-R Raturn | |
| Raturn compatible cages | |
Automated Refrigerated Fraction Collection
| MD-1201 | Refrigerated Dual Channel Fraction Collector |
| MD-1202U | Refrigerated Single Channel Fraction Collector |
Content coming soon
BASi can assist you with setting up your own OFM platform in your lab. Contact us with your request.
Contact us if you are interested in outsourcing a preclinical OFM study with Joanneum Research.
Click to download a/dOFM flyer.
Click for published literature on a/dOFM.
Contact us to request reprints of published articles on aOFM/dOFM.
Read OFM Press Release.
